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European collaborative research to develop lab-on-chip system for cheap and fast cancer diagnosis |
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Written by Saqib Kazmi
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Thursday, 02 September 2010 03:23 |
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Imec and its project partners announce the launch of the European Seventh Framework Project MIRACLE. The MIRACLE project aims at developing an operational lab-on-chip for the isolation and detection of circulating and disseminated tumor cells (CTCs and DTCs) in blood. The new lab-on-chip is an essential step towards faster and cost-efficient diagnosis of cancer. Detection of circulating and disseminated tumor cells in blood is a promising methodology to diagnose cancer dissemination or to follow up cancer patients during therapy. Today, the detection analyses of these cells are performed in medical laboratories requiring labor intensive, expensive and time-consuming sample processing and cell isolation steps. A full tumor cell detection analysis can take more than a day. A lab-on-chip, integrating the many processing steps, would enable a faster, easy-to-use, cost-effective detection of tumor cells in blood. They are therefore labor-saving and minimally invasive, increasing the patient’s comfort and the efficiency of today’s healthcare. In a preceding joint project by some of the partners (MASCOT FP6-027652), individual microfluidic modules for cell isolation, cell counting, DNA amplification and detection have been developed. Based on this expertise and strengthened by additional partners, the development of a fully automated, lab-on-chip platform to isolate, count and genotype CTCs is envisaged within the framework of the MIRACLE project. For genotyping, genetic material (i.e. the mRNA) will be extracted from the cells and multiple cancer related markers will be amplified based on multiplex ligation dependent probe amplification (MLPA) followed by their detection using an array of electrochemical sensors. Full integration of all steps requires innovative research and processing steps that need a combination of the multidisciplinary and unique expertise of the different project partners (ranging from microfluidics to interfacing, miniaturization, and integration skills). The resulting lab-on-chip tumor detection system will be well ahead of the current state-of-the-art, revolutionizing cancer diagnostics and individualized theranostics. Within the framework of the MIRACLE project, imec as project coordinator, collaborates with the Universitat Rovira I Virgili (Spain), the Institut für Mikrotechnik Mainz, AdnaGen, ThinXXs and Consultech (Germany), MRC Holland (The Netherlands), the Oslo University Hospital (Norway), the KTH Royal Institute of Technology, Multi-D and Fujirebio Diagnostics (Sweden), ECCO - the European CanCer Organisation and ICsense (Belgium) and Labman (UK). The project aims at developing a fully automated and integrated microsystem providing the genotype (gene expression profile) of CTCs and DTCs starting from clinical samples. MIRACLE is partly funded by the European Commission (FP7-ICT-2009.3.9).
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Last Updated on Thursday, 02 September 2010 03:23 |
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EMBEDDED COMPUTING: Industrial-rugged CPU board for vision, automation, and control introduced by ADLINK |
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Written by Saqib Kazmi
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Thursday, 02 September 2010 03:16 |
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ADLINK Technology is offering the NuPRO-E330 PICMG 1.3 full-sized system host board (SHB) for applications that need high-performance computing, data security, and maximum data access bandwidth, such as industrial control, automation, and industrial vision. The NuPRO-E330 embedded computing board products support next-generation Intel Core i7/i5/i3 processors at clocks speeds as fast as 3.33 GHz and as much as eight gigabytes of dual-channel DDR3 1066/1333 MHz memory in two DIMM slots. Equipped with the Intel Q57 Express Chipset to provide I/O technologies and high data transfer rates, the NuPRO-E330 computer boards are for modern industrial applications where remote management and data protection are critical. The NuPRO-E330 CPU board supports Intel active management technology 6.0 (Intel AMT 6.0), which enables users to manage assets remotely, reduce downtime, and minimize on-site visits. The NuPRO-E330 single-board computer has an Intel Core i7 processor supporting Intel turbo boost technology that enables processor cores to run faster than the rated operating frequency if the processor is operating below power, temperature, and current specification limits.
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Last Updated on Thursday, 02 September 2010 03:20 |
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AMD Technology Allows Studio to Slice Through Special Effects Work in New “Machete” Film |
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Written by Saqib Kazmi
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Thursday, 02 September 2010 03:07 |
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AMD unveiled its close collaboration with Troublemaker Studios to produce the striking visual effects for the action epic “Machete”, a project for the studio that saw the Troublemaker team finalize more than 500 shots, a personal best made possible with AMD graphics and computing technology. Directed and conceived by Robert Rodriguez (director of “Predators”, “Sin City”, and “Shorts”), and featuring an all-star cast including Danny Trejo, Robert De Niro, Lindsay Lohan and Jessica Alba, “Machete” is set to revitalize the action genre. Described by Rodriguez as a “spaghetti western for day laborers,” the film centers on a former Mexican ex-Federale named Machete, who after being setup, embarks on a quest to seek revenge and clear his name. From start to finish, Troublemaker Studios made use of a unique combination of AMD’s graphics and computing technologies to bring the film to life, pioneering new special effects techniques while cutting down on production time and cost. “I’ve had the idea for ‘Machete’ since meeting Danny Trejo while filming ‘Desperado’ in 1993, and it’s only now after years of refining that idea combined with the advancements in AMD technology, that I’ve been able to bring my creative vision to life in the way I truly envisaged it,” said Robert Rodriguez, co-owner, Troublemaker Studios. “The incredible developments in AMD platform technology continue to fuel my creativity, driving me to push it to its limits. In fact, I’ve made plans to incorporate AMD’s Fusion Render technology into the production of my next film ‘Spy Kids 4’.” AMD technology was integral to realizing Rodriguez’s vision for “Machete”: - Breaking Troublemaker Studio’s personal record: For “Machete”, Troublemaker Studios made use of a unique mix of high-performance AMD hardware, including AMD FirePro V8800 professional graphics accelerators and six-core AMD Opteron processor-based workstations to produce the film on a compressed schedule. A team of ten artists with a post-production period of only six months accomplished 500 final shots with AMD’s platform technology, a personal best for Rodriguez and his Troublemaker Studios team.
- Packing more action in: The Troublemaker Studios team worked to fill the scenes of “Machete” with an incredible level of detail using AMD-based graphics workstations. Extensive set damage, a huge number of bullet holes, and wide-ranging set extensions were all added digitally to give the action movie even more bang for its buck, while sophisticated particle simulations helped more accurately render realistic blood spatters that interact with each other, the actors and objects in the environment.
- Working at the “speed of thought”: “Machete” is a return to the guerrilla-style movie making that made Rodriguez famous, incorporating a myriad of mediums and film-making techniques all of which had to come together seamlessly to achieve Rodriguez’s artistic vision. AMD workstations served as the technological glue that brought everything together. Shots from three different digital camera models, one film camera, camera tracking work using PFTrack, 3D special effects work using Softimage, and compositing work using Nuke, all came together through AMD’s professional grade technology to produce a film that looks as though it has a blockbuster budget.
“Leading graphics and workstation technologies from AMD opened a new world of possibilities for Troublemaker Studios, allowing them to deliver a volume and quality of special effects shots for ‘Machete’ that they’ve never been able to before,” said Charlie Boswell, director of Digital Media and Entertainment at AMD. “With six-core AMD Opteron processors and ATI FirePro V8800 graphics solutions, Robert and his Troublemaker Studios team have delivered a look and vibe as distinct as the plot itself.”
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Last Updated on Thursday, 02 September 2010 03:13 |
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Automated Dynamics delivers machinery to GKN |
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Written by Saqib Kazmi
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Thursday, 02 September 2010 03:02 |
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Automated Dynamics has delivered a new piece of high-performance composite processing equipment to GKN Aerospace. The July 29 announcement notes that the machine was installed in GKN’s new preproduction facility, which will support the Environmental Lightweight Fan (ELF) research program. The program’s goal is to develop an all-composite jet engine fan blade that will improve aircraft performance and reduce emissions. Automated Dynamics’ equipment reportedly will help GKN effectively manufacture the complex, often-curved jet engine structures. CGTech has formed a subsidiary in Brazil. Headquartered in São Paulo, CGTech-Brasil is responsible for marketing, sales, technical support and reseller support throughout South America. “There is a growing demand for simulation of complex machine tools,” says company president Jon Prun. “CGTech is well positioned to provide manufacturers with the skills and technologies they need to be successful.” In conjunction with the office opening, CGTech has launched a Web site in Portuguese: vericut.com.br. At a ribbon cutting ceremony on July 28, officials at Lockheed Martin’s Marietta, Ga., facility formally announced the start of the plant’s F-35 Lightning II center wing production. Center wing assembly for the multirole fifth-generation aircraft began July 30 in a 320,000-ft² (29,730m²) space in the Marietta site’s B-1 aircraft building. The assembly activity could employ more than 600 workers by 2016 as the program ramps up to full-rate production of one aircraft per workday. The program’s center wing assembly operation was established in Marietta to alleviate capacity constraints at the F-35’s final assembly site in Fort Worth, Texas, and to take advantage of available manufacturing capacity and existing fifth-generation aircraft production expertise in Marietta, says the company. HITCO Carbon Composites has announced on July 19 a contract from Boeing Research & Technology (BR&T), the R&D arm of The Boeing. BR&T is developing technology and processes for out-of-autoclave manufacturing of composite structures for next-generation aircraft. Specifically, HITCO will fabricate three large composite spars using prepreg supplied by Cytec Engineered Materials (Tempe, Ariz.). Processing will involve hot drape forming and a combination of automated tape laying and hand layup. The effort is part of the U.S. Air Force-directed Non-Autoclave (Prepreg) Manufacturing Technology Program, cofunded by Boeing and the Defense Advanced Research Projects Agency. HITCO expects to complete this phase of the manufacturing technology program by the end of this year.
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Last Updated on Thursday, 02 September 2010 03:05 |
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