Australian made AI may improve suicide prevention in the future

The loss of any life can be devastating, but the loss of life from suicide is especially tragic. 

Around nine Australians take their own life each day, and it is the leading cause of death for Australians aged 15–44. Suicide attempts are more common, with some estimates stating that they occur up to 30 times as often as deaths.

“Suicide has large effects when it happens. It impacts many people and has far-reaching consequences for family, friends, and communities,” says Karen Kusuma, a UNSW Sydney Ph.D. candidate in psychiatry at the Black Dog Institute, who investigates suicide prevention in adolescents.

Ms. Kusuma and a team of researchers from the Black Dog Institute and the Centre for Big Data Research in Health recently investigated the evidence base of machine learning models and their ability to predict future suicidal behaviors and thoughts. They evaluated the performance of 54 machine learning algorithms previously developed by researchers to predict suicide-related outcomes of ideation, attempt, and death.

The meta-analysis, published in the Journal of Psychiatric Research, found machine learning models outperformed traditional risk prediction models in predicting suicide-related outcomes, which have traditionally performed poorly.  

“Overall, the findings show there is a preliminary but compelling evidence base that machine learning can be used to predict future suicide-related outcomes with very good performance,” Ms. Kusuma says. 

Traditional suicide risk assessment models 

Identifying individuals at risk of suicide is essential for preventing and managing suicidal behaviors. However, risk prediction is difficult.

In emergency departments (EDs), risk assessment tools such as questionnaires and rating scales are commonly used by clinicians to identify patients at elevated risk of suicide. However, evidence suggests they are ineffective in accurately predicting suicide risk in practice.

“While there are some common factors shown to be associated with suicide attempts, what the risks look like for one person may look very different in another,” Ms. Kusuma says. “But suicide is complex, with many dynamic factors that make it difficult to assess a risk profile using this assessment process.”

A post-mortem analysis of people who died by suicide in Queensland found, of those who received a formal suicide risk assessment, 75 percent were classified as low risk, and none was classified as high risk. Previous research examining the past 50 years of quantitative suicide risk prediction models also found they were only slightly better than chance in predicting future suicide risk

“Suicide is a leading cause of years of life lost in many parts of the world, including Australia. But the way suicide risk assessment is done hasn’t developed recently, and we haven’t seen substantial decreases in suicide deaths. In some years, we’ve seen increases,” Ms Kusuma says. 

Despite the shortage of evidence in favor of traditional suicide risk assessments, their administration remains a standard practice in healthcare settings to determine a patient’s level of care and support. Those identified as having a high risk typically receive the highest level of care, while those identified as low risk are discharged. 

“Using this approach, unfortunately, the high-level interventions aren’t being given to the people who really need help. So we must look to reform the process and explore ways we can improve suicide prevention,” Ms. Kusuma says. 

Machine learning suicide screening 

Ms. Kusuma says there is a need for more innovation in suicidology and a re-evaluation of standard suicide risk prediction models. Efforts to improve risk prediction have led to her research using artificial intelligence (AI) to develop suicide risk algorithms. 

“Having AI that could take in a lot more data than a clinician would be able to better recognize which patterns are associated with suicide risk,” Ms. Kusuma says. 

In the meta-analysis study, machine learning models outperformed the benchmarks set previously by traditional clinical, theoretical and statistical suicide risk prediction models. They correctly predicted 66 percent of people who would experience a suicide outcome and correctly predicted 87 percent of people who would not experience a suicide outcome. 

“Machine learning models can predict suicide deaths well relative to traditional prediction models and could become an efficient and effective alternative to conventional risk assessments,” Ms. Kusuma says. 

The strict assumptions of traditional statistical models do not bind machine learning models. Instead, they can be flexibly applied to large datasets to model complex relationships between many risk factors and suicidal outcomes. They can also incorporate responsive data sources, including social media, to identify peaks of suicide risk and flag times where interventions are most needed. 

“Over time, machine learning models could be configured to take in more complex and larger data to better identify patterns associated with suicide risk,” Ms. Kusuma says. 

The use of machine learning algorithms to predict suicide-related outcomes is still an emerging research area, with 80 percent of the identified studies published in the past five years. Ms. Kusuma says future research will also help address the risk of aggregation bias found in algorithmic models to date.

“More research is necessary to improve and validate these algorithms, which will then help progress the application of machine learning in suicidology,” Ms. Kusuma says. “While we’re still a way off implementation in a clinical setting, research suggests this is a promising avenue for improving suicide risk screening accuracy in the future.” 

Korean Artificial Sun discovers new high-temperature plasma operating mode for fusion energy

Plasma configuration of a FIRE mode in Korea Superconducting Tokamak Advanced Research(KSTAR). The colour of lines indicates the ion temperature in keV, where 10 keV corresponds to ~120 million Kelvin.'FIRE mode' expected to resolve operational difficulties of commercial fusion reactors in the future

Korea Institute of Fusion Energy (KFE) and the Seoul National University (SNU) research team announced that they have discovered a new plasma operating mode that can improve plasma performance for fusion energy based on an analysis of plasma operations with ultra-high temperatures over 100 million degrees (Celsius) at the Korea Superconducting Tokamak Advanced Research (KSTAR).

To generate energy through a fusion reaction as occurs in the sun, it is essential to confine super hot and dense plasma in a fusion reactor stably and for long. To secure such a technology, worldwide fusion energy researchers have worked to find the most efficient plasma operating mode through theoretical and experimental studies.

One of the most widely known operating modes is H-mode (High confinement mode). It has been considered the primary plasma operating method for fusion reactors, thereby serving as a benchmark for developing next-generation operating modes.

The main downside of this H-mode, however, is the appearance of plasma instability, the so-called edge-localized mode (ELM) in which the pressure at the edge plasma exceeds the threshold, bursting the plasma like a balloon. Since this can cause damage to the inner walls of a reactor, researchers have been exploring various ways to control the ELM, while trying to develop a more stable plasma operating mode.

By analyzing experimental data of KSTAR operations and analyzing them through simulations, KFE and SNU researchers found that the fast ions, or the high-energy particles generated due to external heating, stabilize the turbulences inside the plasma, resulting in a dramatical increase in the plasma temperature. This newfound plasma regime has been coined “Fast Ion Regulated Enhancement (FIRE) mode“.

Since FIRE mode can improve the plasma performance compared to the H-mode while generating no ELM and providing easier operational control, it expects to open up new possibilities in developing plasma operation technology for commercial fusion reactors down the road, as well as contribute to the operation of the International Thermonuclear Experimental Reactor (ITER).

Japanese built models reveal the determinants of persistent, severe COVID-19

Left. Proportion of DCs in healthy individuals, during acute COVID-19 infection, and 7 months after infection based on simulations and clinical observations (Obs). Right. Comparison of viral loads between the baseline model and the severe symptom models with varying conditions of antigen-reporting DC function (APC) or interferon levels.As COVID-19 wreaks havoc across the globe, one characteristic of the infection has not gone unnoticed. The disease is heterogeneous in nature with symptoms and severity of the condition spanning a wide range. The medical community now believes this is attributed to variations in the human hosts’ biology and has little to do with the virus per se. Shedding some light on this conundrum is Associate Professor SUMI Tomonari from Okayama University, Research Institute for Interdisciplinary Science (RIIS), and Associate Professor Kouji Harada from the Toyohashi University of Technology, the Center for IT-based Education (CITE). The duo recently reported their findings on imbalances in the host immune system that facilitate persistent or severe forms of the disease in some patients.

The researchers commenced their study by supercomputer simulations with models based on a host’s immune system and its natural response to SARS-CoV-2 exposure. Mathematical equations for the dynamics of cells infected by SARS-CoV-2 were plugged in to predict their behavior. Now, the immune system has messenger cells known as dendritic cells (DCs). These cells report information (in the form of antigens) about the invaders to the warriors, or T cells, of the immune system. The model showed that at the onset of infection, DCs from infected tissues were activated, and then antibodies to neutralize SARS-CoV-2 gradually started building.

To investigate long-term COVID-19, the behavior of DCs 7 months after infection was evaluated by the supercomputer simulation. the baseline model simulation revealed that DCs drastically decreased during the peak of infection and slowly built up again. However, they tended to remain below pre-infection levels. These observations were similar to those seen in clinical patient samples. It seemed like low DC levels were associated with tenacious long-term infection.

The subsequent step was to understand if DC function contributed to disease severity. It was found that a deficiency of the antigen-reporting function of DCs and lowered levels of chemicals known as interferons released by them were related to severe symptoms. A decrease in both these functions resulted in higher amounts of virus in the blood (viral load). What’s more, the researchers also found two factors that affected the virus’s ability to replicate in the host, namely, antigen-reporting DCs and the presence of antibodies against the virus. Anomalies in these functions could hamper viral clearance, enabling it to stay in the body longer than expected, whereas a high ability of these immune functions suppresses viral replication and yields prompt viral clearance.

Components of immune signaling that directly affect the outcome of COVID-19 infection were revealed in this study. “ Our mathematical model predicted the persistent DC reduction and showed that certain patients with severe and even mild symptoms could not effectively eliminate the virus and could potentially develop long COVID,” concludes the duo. A better understanding of these immune responses could help shape the prognosis of and therapeutic interventions against COVID-19.