Tyler O'Neal, Staff Editor APPLICATIONS

Novel AI model provides insight into how collective behaviors emerge

How do the stunningly intricate patterns created by schools of fish emerge? For many scientists, this question presents an irresistible mathematical puzzle involving a substantial number of variables describing the relative speed and position of each individual fish and its many neighbors.

Various mathematical models were proposed to tackle this question, but according to Gonzalo de Polavieja, head of the Collective Behaviour lab at the Champalimaud Centre for the Unknown in Lisbon, Portugal, they would inevitably fall into one of two extremes: they would either be too simple, or too complex.

"The rise of the field of artificial intelligence and machine learning has provided models that are very accurate in predicting the behavior of individuals in groups", says de Polavieja. "But these models are like black boxes: The way they process the data to generate their predictions could involve thousands of parameters, many of which may not even correspond to real-world variables. Humans are unable to make sense of such complex information."

"On the other extreme", he continues, "are the simpler models, with few parameters, that allow you to identify rules associated with one main component, such as the distance between the fish, or their relative velocity. But those models are too narrow and therefore are never accurate when it comes to predicting the overall behavior of the group."

Drawing inspiration from a new type of an AI model called "attention networks", de Polavieja and his team were able to identify a solution that lies just between the two extremes: a model that is both insightful and predictive. They describe their results in an article published in the scientific journal Plos Computational Biology.

Deconstructing the black box 214003 web 8b99d

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To solve the problem, the team decided to use AI techniques with a twist: instead of constructing the standard intact "black box", they organized the model into numerous interconnected modules, each of which was simple enough so that it could be analyzed.

When the team studied the functions generated by the individual modules, they found that the coarse rules they already knew still held, but were greatly refined. "For example, according to previous models, the space around each fish is divided into three circular concentric areas: repulsion, alignment, and attraction. We also found those same three areas, but contrary to the simple models that originally identified them, our model showed that the areas were not circular, nor concentric, and that they changed in a manner that depended on the velocity of the fish", explains Francisco Heras, the first author of the study.

In addition to being insightful, the model is also good at predicting the behavior of the fish. "We can tell with 90% accuracy whether each fish in the group will turn right or left during the following second", says Heras. "This may not seem like a long time compared with the timescale humans operate in, but zebrafish live in a faster paced environment and can move a distance of about eight times their body length in a mere second."

The results of the model are so robust that one can't help but wonder why this approach wasn't used before. According to de Polavieja, the answer is "a bit of sociology and a bit of mathematics." As he explains, "since the two approaches dominating the field were so different, it took a while to realize that constructing a model that is both insightful and predictable was even possible." Once the team realized this possibility, they began exploring different architectures and fine-tuning their set of assumptions in a way that optimized the predictive capacity of the model while keeping it simple enough to be insightful.

Another element that made this development possible is the open-source, sophisticated tracking software the lab had recently developed. "By using idtracker.ai, we were able to track groups of 100 fish simultaneously. This was crucial for obtaining the large and detailed dataset necessary for this type of research."

The team made the code for their model freely available. According to Polavieja, it can be a useful tool for the collective behavior community, which will now have a way to recover interaction rules in a way that is automatic, predictive and insightful of the biology. "We hope that it will be used by others to study many different types of social interactions", he concludes.

CU research identifies key uncertainties for models of mosquito distribution in the US

Tyler O'Neal, Staff Editor APPLICATIONS

Understanding model limitations could improve strategies to deal with mosquito-borne diseases

Computational analysis has identified key regions in the United States where model-based predictions of mosquito species distribution could be improved. Andrew Monaghan of the University of Colorado Boulder and colleagues present these findings in PLOS Computational Biology.

Aedes aegypti and Aedes albopictus mosquitoes are globally important species that can transmit dengue, chikungunya, yellow fever, and Zika viruses. However, data on their geographic distribution are very limited. Computational models can help fill in the gaps by providing predictions of where mosquitos may be found, but the accuracy of such models is difficult to gauge. CAPTION An Aedes aegypti mosquito, the vector of chikungunya, dengue, yellow fever, and Zika viruses. CREDIT CDC/ Prof. Frank Hadley Collins.{module In-article}

To address this issue, Monaghan and colleagues assessed and combined previously developed computational models to generate new predictions of the chances of finding Ae. aegypti and Ae. albopictus in each county in the contiguous United States. Then, they compared their estimates with real-world mosquito collection data from each county.

The researchers found that existing models have gaps that had not previously been identified, despite the relatively high availability of mosquito data in the U.S. compared to other countries. They found high uncertainty of the models in predicting the presence of Ae. aegypti and Ae. albopictus across broad regions likely to be borderline habitats for these species. They also discovered key pockets where the models appear to be biased, such as the Florida panhandle and much of the Southwest for Ae. aegypti.

"By comparing analytical models and data, we identified key gaps in mosquito surveillance data and models," says senior author, Michael Johansson. "Understanding those limitations helps us to be better prepared for infectious disease threats today and to focus on key needs to be even better prepared tomorrow."

The findings point to the need for additional data and improved models to advance understanding of the range of mosquito species and the risk of disease transmission around the world. Johansson and colleagues are now organizing an ongoing collaborative project to systematically collect more mosquito data in the United States and analyze new models, shedding new light on species distribution.

UC Riverside astronomers find large-scale winds associated with active black holes in small galaxies suppress star formation

Tyler O'Neal, Staff Editor APPLICATIONS

NGC1569 is a star-forming galaxy.

Astronomers at the University of California, Riverside, have discovered that powerful winds driven by supermassive black holes in the centers of dwarf galaxies have a significant impact on the evolution of these galaxies by suppressing star formation. {module In-article}

Dwarf galaxies are small galaxies that contain between 100 million to a few billion stars. In contrast, the Milky Way has 200-400 billion stars. Dwarf galaxies are the most abundant galaxy type in the universe and often orbit larger galaxies.

The team of three astronomers was surprised by the strength of the detected winds. 

"We expected we would need observations with much higher resolution and sensitivity, and we had planned on obtaining these as a follow-up to our initial observations," said Gabriela Canalizo, a professor of physics and astronomy at UC Riverside, who led the research team. "But we could see the signs strongly and clearly in the initial observations. The winds were stronger than we had anticipated."

Canalizo explained that astronomers have suspected for the past couple of decades that supermassive black holes at the centers of large galaxies can have a profound influence on the way large galaxies grow and age.

"Our findings now indicate that their effect can be just as dramatic, if not more dramatic, in dwarf galaxies in the universe," she said.

Study results appear in The Astrophysical Journal.

The researchers, who also include Laura V. Sales, an assistant professor of physics and astronomy; and Christina M. Manzano-King, a doctoral student in Canalizo's lab, used a portion of the data from the Sloan Digital Sky Survey, which maps more than 35% of the sky, to identify 50 dwarf galaxies, 29 of which showed signs of being associated with black holes in their centers. Six of these 29 galaxies showed evidence of winds -- specifically, high-velocity ionized gas outflows -- emanating from their active black holes.

"Using the Keck telescopes in Hawaii, we were able to not only detect, but also measure specific properties of these winds, such as their kinematics, distribution, and power source -- the first time this has been done," Canalizo said. "We found some evidence that these winds may be changing the rate at which the galaxies are able to form stars."

Manzano-King, the first author of the research paper, explained that many unanswered questions about galaxy evolution can be understood by studying dwarf galaxies.

"Larger galaxies often form when dwarf galaxies merge together," she said. "Dwarf galaxies are, therefore, useful in understanding how galaxies evolve. Dwarf galaxies are small because after they formed, they somehow avoided merging with other galaxies. Thus, they serve as fossils by revealing what the environment of the early universe was like. Dwarf galaxies are the smallest galaxies in which we are directly seeing winds -- gas flows up to 1,000 kilometers per second -- for the first time."

Manzano-King explained that as material falls into a black hole, it heats up due to friction and strong gravitational fields and releases radiative energy. This energy pushes ambient gas outward from the center of the galaxy into intergalactic space.

"What's interesting is that these winds are being pushed out by active black holes in the six dwarf galaxies rather than by stellar processes such as supernovae," she said. "Typically, winds driven by stellar processes are common in dwarf galaxies and constitute the dominant process for regulating the amount of gas available in dwarf galaxies for forming stars."

Astronomers suspect that when wind emanating from a black hole is pushed out, it compresses the gas ahead of the wind, which can increase star formation. But if all the wind gets expelled from the galaxy's center, gas becomes unavailable and star formation could decrease. The latter appears to be what is occurring in the six dwarf galaxies the researchers identified.

"In these six cases, the wind has a negative impact on star formation," Sales said. "Theoretical models for the formation and evolution of galaxies have not included the impact of black holes in dwarf galaxies. We are seeing evidence, however, of a suppression of star formation in these galaxies. Our findings show that galaxy formation models must include black holes as important, if not dominant, regulators of star formation in dwarf galaxies."

Next, the researchers plan to study the mass and momentum of gas outflows in dwarf galaxies.

"This would better inform theorists who rely on such data to build models," Manzano-King said. "These models, in turn, teach observational astronomers just how the winds affect dwarf galaxies. We also plan to do a systematic search in a larger sample of the Sloan Digital Sky Survey to identify dwarf galaxies with outflows originating in active black holes."